We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Bcl-2 Family in Host-Virus Interactions.
- Authors
Kvansakul, Marc; Caria, Sofia; Hinds, Mark G.
- Abstract
Members of the B cell lymphoma-2 (Bcl-2) family are pivotal arbiters of mitochondrially mediated apoptosis, a process of fundamental importance during tissue development, homeostasis, and disease. At the structural and mechanistic level, the mammalian members of the Bcl-2 family are increasingly well understood, with their interplay ultimately deciding the fate of a cell. Dysregulation of Bcl-2-mediated apoptosis underlies a plethora of diseases, and numerous viruses have acquired homologs of Bcl-2 to subvert host cell apoptosis and autophagy to prevent premature death of an infected cell. Here we review the structural biology, interactions, and mechanisms of action of virus-encoded Bcl-2 proteins, and how they impact on host-virus interactions to ultimately enable successful establishment and propagation of viral infections.
- Subjects
BCL-2 proteins; APOPTOSIS; HOMEOSTASIS; HOST-virus relationships; POXVIRUSES
- Publication
Viruses (1999-4915), 2017, Vol 9, Issue 10, p290
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v9100290