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- Title
Porcine Epidemic Diarrhea Virus Induces Autophagy to Benefit Its Replication.
- Authors
Xiaozhen Guo; Mengjia Zhang; Xiaoqian Zhang; Xin Tan; Hengke Guo; Wei Zeng; Guokai Yan; Memon, Atta Muhammad; Zhonghua Li; Yinxing Zhu; Bingzhou Zhang; Xugang Ku; Meizhou Wu; Shengxian Fan; Qigai He
- Abstract
The new porcine epidemic diarrhea (PED) has caused devastating economic losses to the swine industry worldwide. Despite extensive research on the relationship between autophagy and virus infection, the concrete role of autophagy in porcine epidemic diarrhea virus (PEDV) infection has not been reported. In this study, autophagy was demonstrated to be triggered by the effective replication of PEDV through transmission electron microscopy, confocal microscopy, andWestern blot analysis. Moreover, autophagy was confirmed to benefit PEDV replication by using autophagy regulators and RNA interference. Furthermore, autophagy might be associated with the expression of inflammatory cytokines and have a positive feedback loop with the NF-кB signaling pathway during PEDV infection. This work is the first attempt to explore the complex interplay between autophagy and PEDV infection. Our findings might accelerate our understanding of the pathogenesis of PEDV infection and provide new insights into the development of effective therapeutic strategies.
- Subjects
PORCINE epidemic diarrhea virus; PORCINE somatotropin; AUTOPHAGY; TRANSMISSION electron microscopy; WESTERN immunoblotting
- Publication
Viruses (1999-4915), 2017, Vol 9, Issue 3, p53
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v9030053