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- Title
HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus.
- Authors
Guerrero, Santiago; Batisse, Julien; Libre, Camille; Bernacchi, Serena; Marquet, Roland; Paillart, Jean-Christophe
- Abstract
Eukaryotic translation is a complex process composed of three main steps: initiation, elongation, and termination. During infections by RNA- and DNA-viruses, the eukaryotic translation machinery is used to assure optimal viral protein synthesis. Human immunodeficiency virus type I (HIV-1) uses several non-canonical pathways to translate its own proteins, such as leaky scanning, frameshifting, shunt, and cap-independent mechanisms. Moreover, HIV-1 modulates the host translation machinery by targeting key translation factors and overcomes different cellular obstacles that affect protein translation. In this review, we describe how HIV-1 proteins target several components of the eukaryotic translation machinery, which consequently improves viral translation and replication.
- Subjects
HIV infection risk factors; EUKARYOTIC cells; MOLECULAR structure of RNA; CHEMICAL synthesis; RIBOSOME structure; RIBOSOMAL DNA
- Publication
Viruses (1999-4915), 2015, Vol 7, Issue 1, p199
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v7010199