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- Title
pH-sensitive polymeric micelles enhance the co-delivery of doxorubicin and docetaxel: an emerging modality for treating breast cancer.
- Authors
Farhoudi, Leila; Hosseinikhah, Seyedeh Maryam; Kazemi-Beydokhti, Amin; Arabi, Leila; Alavizadeh, Seyedeh Hoda; Moosavian, Seyedeh Alia; Jaafari, Mahmoud Reza
- Abstract
Background: Designing and preparing a co-delivery system based on polymeric micelles have attracted in recent years. Co-delivery of anti-cancer agents within pH-sensitive polymeric micelles could provide superior advantages over the co-administration of free drugs, since it enables simultaneous delivery of drugs to reach an optimum synergistic dose right to the tumor. Methods: DOX was conjugated to the polymer through a hydrazine linker by Schiff's base reaction. Then, DTX was encapsulated into the core of the polymer to the resulting DOX-Hyd-PM/DTX micelle with optimum molar ratios of 1:1 and 1:5 (DOX/DTX). Results: The final formulations showed the desired particle size and increased release of DOX and DTX in acidic media (pH 5.5). The cytotoxicity assay of DOX-Hyd-PM/DTX indicated the highest synergistic effect on both 4T1 and TUBO cell lines over other formulations. Interestingly, in accordance with in vitro results, DOX-Hyd-PM/DTX revealed a promising anti-tumor activity in mice-bearing 4T1 breast cancer tumor with higher tumor accumulation of DOX and DTX after 24 h compared to free drugs combination. Conclusions: These findings point to the potential use of such smart nanodrug delivery systems in cancer treatment, where the synergistic effect of both drugs may be used to enhance therapeutic response.
- Subjects
DOCETAXEL; BREAST cancer; SCHIFF bases; MICELLES; DOXORUBICIN; ANTINEOPLASTIC agents
- Publication
Cancer Nanotechnology (1868-6958), 2024, Vol 15, Issue 1, p1
- ISSN
1868-6958
- Publication type
Article
- DOI
10.1186/s12645-024-00275-1