We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I.
- Authors
Begum-Ali, Jannath; Kolesnik-Taylor, Anna; Quiroz, Isabel; Mason, Luke; Garg, Shruti; Green, Jonathan; Johnson, Mark H.; Jones, Emily J. H.; the STAARS and EDEN Teams; Holman, Rebecca; Kalwarowsky, Sarah; Pirazzoli, Laura; Taylor, Chloë; Vassallo, Grace; Burkitt-Wright, Emma; Eelloo, Judith; Evans, D. Gareth; West, Siobhan; Hupton, Eileen; Lewis, Lauren
- Abstract
Background: Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies. Methods: In this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD. Results: In typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits. Conclusions: These findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD.
- Subjects
NEUROFIBROMATOSIS in children; AUDITORY processing disorder; AUTISM spectrum disorders in children; HABITUATION (Neuropsychology); ELECTROENCEPHALOGRAPHY
- Publication
Journal of Neurodevelopmental Disorders, 2021, Vol 13, Issue 1, p1
- ISSN
1866-1947
- Publication type
Article
- DOI
10.1186/s11689-021-09364-3