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- Title
Brain Temperature, Choline, N-Acetyl-Aspartate, and Myo-Inositol Measured by MRS Can Only Be Considered Diagnostic Biomarkers if Their Criteria are Met [Letter].
- Authors
Finsterer, Josef
- Abstract
This article discusses a study that used magnetic resonance spectroscopy (MRS) to measure brain temperature and metabolites in patients with functional seizures, psychiatric controls, and healthy controls. The study found that brain temperature was higher in patients with functional seizures compared to healthy controls in certain areas of the brain, and lower in the frontal lobe and cerebellum in psychiatric controls. The study also found differences in metabolite levels between the groups. However, the article points out that abnormalities in MRS are generally nonspecific and can be seen in various other conditions, and that psychiatric patients may not be the ideal control group. The article suggests that further research is needed to exclude other potential causes and to use additional diagnostic methods alongside MRS.
- Subjects
CHOLINE; PSYCHOGENIC nonepileptic seizures; BIOMARKERS; PERIPHERAL nervous system; PROGRESSIVE multifocal leukoencephalopathy
- Publication
Neuropsychiatric Disease & Treatment, 2024, Vol 20, p897
- ISSN
1178-2021
- Publication type
Article
- DOI
10.2147/NDT.S472369