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- Title
Association between OLR1 K167N SNP and Intima Media Thickness of the Common Carotid Artery in the General Population.
- Authors
Predazzi, Irene Marta; Norata, Giuseppe Danilo; Vecchione, Lucia; Garlaschelli, Katia; Amati, Francesca; Grigore, Liliana; Cutuli, Lucia; Pirillo, Angela; Tramontana, Simona; Romeo, Francesco; Novelli, Giuseppe; Catapano, Alberico Luigi
- Abstract
Background and Purpose: The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent. Methods - We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study). Results: Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers. Conclusions: These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process.
- Subjects
CAROTID artery; LECTINS; GENETIC code; LOW density lipoprotein receptors; ATHEROSCLEROSIS; MESSENGER RNA; GENE expression
- Publication
PLoS ONE, 2012, Vol 7, Issue 2, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0031086