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- Title
Cobalt‐Catalyzed Direct C(sp<sup>2</sup>)–H Alkylation with Unactivated Alkenes.
- Authors
Kim, Ye Lim; Park, Sun‐a; Kim, Ju Hyun
- Abstract
A facile and efficient method for Cp*CoIII‐catalyzed C(sp2)–H bond alkylation was developed using 2‐aryl pyridines and unactivated alkenes. The reaction proceeded atom‐economically with readily available styrene derivatives and an abundant cobalt catalyst. This reaction tolerates a broad range of functional groups, directing groups, styrenes and affords mono‐diarylethane products with high linear selectivity. To demonstrate the synthetic utility and the potential application in organic synthesis, a gram‐scale reaction and further C–H bond functionalizations of the mono‐alkylated product were performed.
- Subjects
ALKYLATION; ALKENES; COBALT catalysts; STYRENE derivatives; ORGANIC synthesis
- Publication
European Journal of Organic Chemistry, 2020, Vol 2020, Issue 26, p4026
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202000565