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- Title
Rhodium-Catalyzed [4+3] Cycloaddition to Furans: Direct Access to Functionalized Bicyclo[5.3.0]decane Derivatives.
- Authors
Krainz, Tanja; Chow, Sharon; Korica, Natasa; Bernhardt, Paul V.; Boyle, Glen M.; Parsons, Peter G.; Davies, Huw M. L.; Williams, Craig M.
- Abstract
An efficient method to directly access the bicyclo[5.3.0]decane core was achieved by rhodium-catalyzed reaction of a novel donor-acceptor cyclopentenyl diazocarboxylate with a variety of furans. As this motif is commonly found within bioactive antitumor natural products, selected systems were further manipulated and evaluated against cancer cell lines sensitive to protein kinase C (PKC) activation.
- Subjects
BICYCLODECENES; RHODIUM; CARBOXYLATES; FURANS synthesis; PROTEIN kinase C
- Publication
European Journal of Organic Chemistry, 2016, Vol 2016, Issue 1, p41
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201501271