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- Title
Women Infected with HIV Type 1 Brazilian Variant, Subtype B (B'-GWGR Motif) Have Slower Progression to AIDS, Compared with Patients Infected with Subtype B (B-GPGR Motif).
- Authors
de Brito, Adriana; Komninakis, Shirley C. V.; Novoa, Patrícia; de Oliveira, Rafael M.; Fonseca, Luiz Augusto M.; Duarte, Alberto J. S.; Casseb, Jorge
- Abstract
Introduction. The Brazilian variant of human immunodeficiency virus (HIV) type 1 (HIV-1) subtype B (serotype B′-GWGR) has a tryptophan replacing a proline in position 328 of the HIV-1 envelope, a feature that may induce a different HIV disease progression. We aimed to evaluate the role of the B subtypes of HIV-1 (serotypes B-GPGR and B′-GWGR) on HIV disease progression. Methods. A total of 137 HIV-infected individuals who had been admitted to the hospital were tested with an anti-V3 serologic assay, using peptides representing 2 HIV-1 subtype B strains, MN and SF2, and 2 Brazilian variant B′-GWGR strains, BR1 and BR2. Results. Of 137 serum samples tested with the anti-V3 serologic assay, 4 (3%) yielded indeterminate results, 74 (54%; from 25 women and 49 men) were found to be B-GPGR, and 59 (43%; from 20 women and 39 men) were found to be the B′-GWGR variant. In general, a longer interval from the first known positive HIV test result to an AIDS-defining event was observed in the B′-GWGR group than in the B-GPGR group (21 vs. 7 months). The CD4+ T cell counts were higher in the B′-GWGR group (median CD4+ T cell count, 65 vs. 31 cells/mm³; P = .01), and women infected with the B′-GWGR variant were less likely to die than were men infected with the same variant (P = .01). The median viral load in the B′-GWGR group was 3.395 copies/mL, compared with 39.350 copies/mL in the B-GPGR group (P = .01). Conclusions. Taken together, our results indicate that B′-GWGR-infected women may have more-favorable outcomes than B-GPGR-infected subjects.
- Subjects
HIV; HIV infections; TRYPTOPHAN; AMINO acids; ORGANIC cyclic compounds; BLOOD plasma
- Publication
Clinical Infectious Diseases, 2006, Vol 43, Issue 11, p1476
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/508875