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- Title
Longitudinal clinical trials with adaptive choice of follow-up time.
- Authors
Jeffries, Neal; Geller, Nancy L.
- Abstract
In longitudinal studies comparing two treatments with a maximum follow-up time there may be interest in examining treatment effects for intermediate follow-up times. One motivation may be to identify the time period with greatest treatment difference when there is a non-monotone treatment effect over time; another motivation may be to make the trial more efficient in terms of time to reach a decision on whether a new treatment is efficacious or not. Here, we test the composite null hypothesis of no difference at any follow-up time versus the alternative that there is a difference at at least one follow-up time. The methods are applicable when a few measurements are taken over time, such as in early longitudinal trials or in ancillary studies. Suppose the test statistic
- Subjects
BIOMETRIC research; NULL hypothesis; LONGITUDINAL method; STATISTICAL research; MATHEMATICAL statistics
- Publication
Biometrics, 2015, Vol 71, Issue 2, p469
- ISSN
0006-341X
- Publication type
Article
- DOI
10.1111/biom.12287