We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of hormone therapy with estrogen and/or progesterone on sleep pattern in postmenopausal women
- Authors
Hachul, Helena; Bittencourt, Lia R.A.; Andersen, Monica L.; Haidar, Mauro A.; Baracat, Edmund C.; Tufik, Sergio
- Abstract
<bold>Objective: </bold>To investigate the effects of estrogen and progesterone on sleep in postmenopausal women.<bold>Method: </bold>The 33 participants were randomly assigned to an estrogen or placebo group after undergoing clinical and hormonal assessments and a polysomnogram, and they underwent the same tests again after 12 weeks. Then, while still taking estrogen or placebo, they all received progesterone for another 12 weeks and underwent a final polysomnogram.<bold>Results: </bold>Estrogen plus progesterone was more effective than estrogen alone in decreasing the prevalence of periodic limb movement (PLM) (8.1% vs 2.8%), hot flashes (14.2% vs 0%), and bruxism (11.1% vs 0%) at night, or somnolence and attention difficulty during the day. The prevalences of breathing irregularities, arousal from sleep, anxiety, and memory impairment were decreased in both groups following progesterone treatment.<bold>Conclusion: </bold>While not significantly affecting sleep quality, hormone therapy decreased the prevalence of arousal in both groups and that of PLM in the group treated with estrogen plus progesterone.
- Subjects
HORMONE therapy; ESTROGEN; PROGESTERONE; SLEEP-wake cycle; ESTROGEN replacement therapy; THERAPEUTIC use of progestational hormones; COGNITION disorders; COMPARATIVE studies; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PROGESTATIONAL hormones; RESEARCH; STATISTICAL sampling; SLEEP; POLYSOMNOGRAPHY; EVALUATION research; RANDOMIZED controlled trials; TREATMENT effectiveness; DISEASE prevalence; BLIND experiment; POSTMENOPAUSE; HOT flashes; THERAPEUTICS
- Publication
International Journal of Gynecology & Obstetrics, 2008, Vol 103, Issue 3, p207
- ISSN
0020-7292
- Publication type
journal article
- DOI
10.1016/j.ijgo.2008.07.009