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- Title
Relationships Between β<sub>2</sub>-Microglobulin and Alloantigens Coded for by the Major Histocompatibility Complexes of the Rabbit and the Guinea Pig.
- Authors
Bjorck, L.; Cigén, R.; Berggård, B.; B. Löw; Berggård, I.
- Abstract
Treatment of rabbit and guinea pig lymphocytes with Fab' fragments of anti-β2-microglobulin completely inhibited the cytotoxic effects of alloantisera to RLA or GPLA antigens, respectively. Aggregation of β2-microglobulin on the lymphocyte surface by successive incubations with goat anti-β2-microglobulin and F(ab')2 fragments of rabbit anti-goat IgG also made rabbit lymphocytes resistant to lysis by anti-RLA, and guinea pig lymphocytes resistant to lysis by anti-GPLA. The two kinds of pretreatment of guinea pig lymphocytes did not affect the cyto-toxicity of antisera directed against guinea pig Ia antigens. These results in conjunction with previous findings in the mouse and in man suggest that β2-micro- globulin on the lymphocyte surface in mammals is generally associated with major serologically defined histocompatibility antigens but not with I-region-associated antigens.
- Subjects
MAJOR histocompatibility complex; IMMUNOGENETICS; ANTIGENS; IMMUNOGLOBULIN G; LYMPHOCYTES; LEUCOCYTES
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 10, p1063
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb00342.x