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- Title
Lymphocyte Chimerism After Bone Marrow Transplantation.
- Authors
Hansen, G. S.; Dupont, B.; Faber, V.; Jakobsen, B. K.; Juhl, F.; Nielsen, L. S.; Svejgaard, A.; Thomsen, M.; Wiik, A.
- Abstract
Specific HLA antibodies were used to eliminate donor and recipient cells, respectively, from lymphocyte suspensions prepared from the blood of a child who had been transplanted with bone marrow from an HLA-A- and HLA-B-incompatible, HLA-D-compatible donor. About 70% of the lymphocytes were of donor HLA type, the remaining of recipient type. The phytohemagglutinin-responsive lymphocytes were exclusively limited to the lymphocyte population carrying donor-type HLA antigens. Membrane immunofluorescence investigations of the donor and recipient populations showed a low percentage of IgM-positive lymphocytes in the donor population and an extremely high proportion of IgM-positive lymphocytes in the recipient population. About 90% of the donor lymphocytes were T cells, as judged by their capacity to form rosettes between sheep erythrocytes and T lymphocytes; no cells in the recipient cell population expressed this ability.
- Subjects
HLA histocompatibility antigens; LYMPHOCYTES; IMMUNOGLOBULINS; T cells; IMMUNOGLOBULIN M; IMMUNE system
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 4, p299
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb00397.x