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- Title
Immunization of Saimiri sciureus Monkeys with Plasmodium falciparum Merozoite Surface Protein-3 and Glutamate-Rich Protein Suggests that Protection is Related to Antibody Levels.
- Authors
Carvalho, L. J. M.; Oliveira, S. G.; Theisen, M.; Alves, F. A.; Andrade, M. C. R.; Zanini, G. M.; Brigido, M. C. O.; Oeuvray, C.; Póvoa, M. M.; Muniz, J. A. P. C.; Druilhe, P.; Daniel-Ribeiro, C. T.
- Abstract
The immunogenicity and protective efficacy of various antigen-adjuvant formulations derived either from the merozoite-surface protein-3 (MSP-3) or the glutamate-rich protein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These proteins were selected for immunogenicity studies based primarily on their capacity of inducing an antibody-dependent cellular inhibition effect on parasite growth. Some of the S. sciureus monkeys immunized with MSP-3212−380-AS02 or GLURP27−500-alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) strain] blood-stage infection, and this protection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection using adjuvants that are acceptable for human use and this should trigger further studies with those new antigens.
- Subjects
IMMUNIZATION; SQUIRREL monkeys; PLASMODIUM falciparum; BACTERIAL proteins; IMMUNOGENETICS; IMMUNOGLOBULINS; MALARIA immunology
- Publication
Scandinavian Journal of Immunology, 2004, Vol 59, Issue 4, p363
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.0300-9475.2004.01409.x