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- Title
Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis.
- Authors
Kawajiri, M.; Mogi, M.; Higaki, N.; Matsuoka, T.; Ohyagi, Y.; Tsukuda, K.; Kohara, K.; Horiuchi, M.; Miki, T.; Kira, J. I.
- Abstract
Background We reported a reduction in the levels of angiotensin II in cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS). Objective and methods To clarify the mechanism underlying this reduction, we assayed angiotensin-converting enzyme (ACE) and ACE2 concentrations along with angiotensin II concentrations in CSF samples from 20 patients with MS and 17 controls with non-neurological diseases. Results ACE levels were significantly elevated in patients with MS compared with controls (48.42 ± 4.84 vs 44.71 ± 3.9 pg/mL), whereas ACE2 levels were significantly reduced (2.56 ± 0.26 vs 2.78 ± 0.24 pg/mL), acting toward a normalization of angiotensin II levels. Conclusion These results further indicate an alteration of the intrathecal renin-angiotensin system in patients with MS.
- Subjects
ANGIOTENSIN converting enzyme; CEREBROSPINAL fluid; MULTIPLE sclerosis; RENIN-angiotensin system; ANGIOTENSINS; DEMYELINATION; PATIENTS
- Publication
Multiple Sclerosis (13524585), 2009, Vol 15, Issue 2, p262
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458508097923