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Retargeting azithromycin analogues to have dual-modality antimalarial activity.
Published in:
BMC Biology, 2020, v. 18, n. 1, p. N.PAG, doi. 10.1186/s12915-020-00859-4
By:
- Burns, Amy L.;
- Sleebs, Brad E.;
- Siddiqui, Ghizal;
- De Paoli, Amanda E.;
- Anderson, Dovile;
- Liffner, Benjamin;
- Harvey, Richard;
- Beeson, James G.;
- Creek, Darren J.;
- Goodman, Christopher D.;
- McFadden, Geoffrey I.;
- Wilson, Danny W.
Publication type:
Article
Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii.
Published in:
BMC Biology, 2020, v. 18, n. 1, p. 1, doi. 10.1186/s12915-020-00791-7
By:
- Kloehn, Joachim;
- Oppenheim, Rebecca D.;
- Siddiqui, Ghizal;
- De Bock, Pieter-Jan;
- Kumar Dogga, Sunil;
- Coute, Yohann;
- Hakimi, Mohamed-Ali;
- Creek, Darren J.;
- Soldati-Favre, Dominique
Publication type:
Article
Cell biological analysis reveals an essential role for Pfcerli2 in erythrocyte invasion by malaria parasites.
Published in:
Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03020-9
By:
- Liffner, Benjamin;
- Balbin, Juan Miguel;
- Shami, Gerald J.;
- Siddiqui, Ghizal;
- Strauss, Jan;
- Frölich, Sonja;
- Heinemann, Gary K.;
- Edwards, Ella May;
- Alder, Arne;
- Wichers, Jan Stephan;
- Creek, Darren J.;
- Tilley, Leann;
- Dixon, Matthew W. A.;
- Gilberger, Tim-Wolf;
- Wilson, Danny W.
Publication type:
Article
Targeting malaria parasites with novel derivatives of azithromycin.
Published in:
Frontiers in Cellular & Infection Microbiology, 2022, v. 12, p. 1, doi. 10.3389/fcimb.2022.1063407
By:
- Burns, Amy L.;
- Sleebs, Brad E.;
- Gancheva, Maria;
- McLean, Kimberley T.;
- Siddiqui, Ghizal;
- Venter, Henrietta;
- Beeson, James G.;
- O’Handley, Ryan;
- Creek, Darren J.;
- Ma, Shutao;
- Frölich, Sonja;
- Goodman, Christopher D.;
- McFadden, Geoffrey I.;
- Wilson, Danny W.
Publication type:
Article
Identification of essential exported Plasmodium falciparum protein kinases in malaria‐infected red blood cells.
Published in:
British Journal of Haematology, 2020, v. 188, n. 5, p. 774, doi. 10.1111/bjh.16219
By:
- Siddiqui, Ghizal;
- Proellochs, Nicholas I.;
- Cooke, Brian M.
Publication type:
Article
A new mass spectral library for high-coverage and reproducible analysis of the Plasmodium falciparum–infected red blood cell proteome.
Published in:
GigaScience, 2022, v. 11, p. 1, doi. 10.1093/gigascience/giac008
By:
- Siddiqui, Ghizal;
- De Paoli, Amanda;
- MacRaild, Christopher A;
- Sexton, Anna E;
- Boulet, Coralie;
- Shah, Anup D;
- Batty, Mitchell B;
- Schittenhelm, Ralf B;
- Carvalho, Teresa G;
- Creek, Darren J
Publication type:
Article
Plasma Proteome Association and Catalytic Activity of Stealth Polymer-Grafted Iron Oxide Nanoparticles.
Published in:
Small, 2017, v. 13, n. 36, p. n/a, doi. 10.1002/smll.201701528
By:
- Wang, Miaoyi;
- Siddiqui, Ghizal;
- Gustafsson, Ove J. R.;
- Käkinen, Aleksandr;
- Javed, Ibrahim;
- Voelcker, Nicolas H.;
- Creek, Darren J.;
- Ke, Pu Chun;
- Davis, Thomas P.
Publication type:
Article
Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues.
Published in:
PLoS Pathogens, 2018, v. 14, n. 4, p. 1, doi. 10.1371/journal.ppat.1006918
By:
- Tjhin, Erick T.;
- Spry, Christina;
- Sewell, Alan L.;
- Hoegl, Annabelle;
- Barnard, Leanne;
- Sexton, Anna E.;
- Siddiqui, Ghizal;
- Howieson, Vanessa M.;
- Maier, Alexander G.;
- Creek, Darren J.;
- Strauss, Erick;
- Marquez, Rodolfo;
- Auclair, Karine;
- Saliba, Kevin J.
Publication type:
Article
Sulfoxide‐Containing Polymer‐Coated Nanoparticles Demonstrate Minimal Protein Fouling and Improved Blood Circulation.
Published in:
Advanced Science, 2020, v. 7, n. 13, p. 1, doi. 10.1002/advs.202000406
By:
- Qiao, Ruirui;
- Fu, Changkui;
- Li, Yuhuan;
- Qi, Xiaole;
- Ni, Dalong;
- Nandakumar, Aparna;
- Siddiqui, Ghizal;
- Wang, Haiyan;
- Zhang, Zheng;
- Wu, Tingting;
- Zhong, Jian;
- Tang, Shi‐Yang;
- Pan, Shuaijun;
- Zhang, Cheng;
- Whittaker, Michael R.;
- Engle, Jonathan W.;
- Creek, Darren J.;
- Caruso, Frank;
- Ke, Pu Chun;
- Cai, Weibo
Publication type:
Article
Red Blood Cell BCL-x L Is Required for Plasmodium falciparum Survival: Insights into Host-Directed Malaria Therapies.
Published in:
Microorganisms, 2022, v. 10, n. 4, p. N.PAG, doi. 10.3390/microorganisms10040824
By:
- Boulet, Coralie;
- Siddiqui, Ghizal;
- Gaynor, Taylah L.;
- Doerig, Christian;
- Creek, Darren J.;
- Carvalho, Teresa G.
Publication type:
Article
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy.
Published in:
eLife, 2024, p. 1, doi. 10.7554/eLife.92990
By:
- Giannangelo, Carlo;
- Challis, Matthew P.;
- Siddiqui, Ghizal;
- Edgar, Rebecca;
- Malcolm, Tess R.;
- Webb, Chaille T.;
- Drinkwater, Nyssa;
- Vinh, Natalie;
- Macraild, Christopher;
- Counihan, Natalie;
- Duffy, Sandra;
- Wittlin, Sergio;
- Devine, Shane M.;
- Avery, Vicky M.;
- De Koning-Ward, Tania;
- Scammells, Peter;
- McGowan, Sheena;
- Creek, Darren J.
Publication type:
Article
Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway.
Published in:
eLife, 2022, p. 1, doi. 10.7554/eLife.80813
By:
- Edgar, Rebecca C. S.;
- Siddiqui, Ghizal;
- Hjerrild, Katheryn;
- Malcolm, Tess R.;
- Vinh, Natalie B.;
- Webb, Chaille T.;
- Holmes, Clare;
- MacRaild, Christopher A.;
- Chernih, Hope C.;
- Suen, Willy W.;
- Counihan, Natalie A.;
- Creek, Darren J.;
- Scammells, Peter J.;
- McGowan, Sheena;
- de Koning-Ward, Tania F.
Publication type:
Article
Bio‐Mimicking Brain Vasculature to Investigate the Role of Heterogeneous Shear Stress in Regulating Barrier Integrity.
Published in:
Advanced Biology, 2022, v. 6, n. 12, p. 1, doi. 10.1002/adbi.202200152
By:
- Mehta, Ami;
- Desai, Anal;
- Rudd, David;
- Siddiqui, Ghizal;
- Nowell, Cameron J.;
- Tong, Ziqiu;
- Creek, Darren J.;
- Tayalia, Prakriti;
- Gandhi, Prasanna S.;
- Voelcker, Nicolas H.
Publication type:
Article
Multi-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum.
Published in:
2017
By:
- Siddiqui, Ghizal;
- Srivastava, Anubhav;
- Russell, Adrian S.;
- Creek, Darren J.
Publication type:
journal article
System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion.
Published in:
PLoS Pathogens, 2020, v. 16, n. 6, p. 1, doi. 10.1371/journal.ppat.1008485
By:
- Giannangelo, Carlo;
- Siddiqui, Ghizal;
- De Paoli, Amanda;
- Anderson, Bethany M.;
- Edgington-Mitchell, Laura E.;
- Charman, Susan A.;
- Creek, Darren J.
Publication type:
Article

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