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- Title
Circulating ACE is a predictor of weight loss maintenance not only in overweight and obese women, but also in men.
- Authors
Wang, P; Holst, C; Wodzig, W K W H; Andersen, M R; Astrup, A; van Baak, M A; Larsen, T M; Jebb, S A; Kafatos, A; Pfeiffer, A F H; Martinez, J A; Handjieva-Darlenska, T; Kunesova, M; Viguerie, N; Langin, D; Saris, W H M; Mariman, E C M
- Abstract
BACKGROUND:Circulating angiotensin-converting enzyme (ACE) was identified as a predictor of weight loss maintenance in overweight/obese women of the Diogenes project.OBJECTIVE:To investigate whether ACE acted also as a predictor in men of the Diogenes study and to compare it with that in women.DESIGN:Subjects, who lost 8% of body weight induced by low-caloric diet in an 8-week weight loss period, were assigned to weight loss maintenance with dietary intervention for 6 months.SUBJECTS:125 overweight/obese healthy men from eight European countries who completed whole intervention.MEASUREMENTS:Concentrations and activity of serum ACE at baseline and after the 8-week weight loss, in addition to anthropometric and physiological parameters.RESULTS:Serum ACE concentration decreased by 11.3±10.6% during the weight loss period in men. A greater reduction is associated with less body weight regain during the maintenance period (r=0.227, P=0.012). ACE change was able to predict a weight regain 20% after 6 months, with an odds ratio of 1.59 (95% confidence interval (CI): 1.09-2.33, P=0.016) for every 10% reduction, which was independent of body mass index and weight loss. The prediction power was weaker in men than in women, but without a significant sex difference (P=0.137). In pooled subjects (N=218), the odds ratio was 1.96 (95% CI: 1.46-2.64, P<0.001).CONCLUSIONS:A greater reduction of ACE during weight loss is favorable for weight maintenance in both men and women. This can offer useful information for personalized advice to improve weight loss maintenance. It also confirms the role of ACE in the metabolic pathways of weight regulation.
- Subjects
ANGIOTENSIN converting enzyme; WEIGHT loss; OVERWEIGHT women; SEX differences (Biology); LOW-calorie diet; REGULATION of body weight; BODY mass index
- Publication
International Journal of Obesity, 2012, Vol 36, Issue 12, p1545
- ISSN
0307-0565
- Publication type
Article
- DOI
10.1038/ijo.2011.278