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- Title
Atropine inhibits the increase in gastric emptying during hypoglycemia in humans.
- Authors
Schvarcz, Erik; Palmér, Mats; Åman, Jan; Berne, Christian; Schvarcz, E; Palmér, M; Aman, J; Berne, C
- Abstract
<bold>Objective: </bold>To study the effect of a cholinergic muscarinic blockade on the gastric emptying rate during insulin-induced hypoglycemia in healthy subjects.<bold>Research Design and Methods: </bold>In eight healthy subjects, the rate of gastric emptying of an isotope-labeled meal was assessed by a scintigraphic technique during normoglycemia and hypoglycemia with simultaneous infusion of either atropine or saline. Blood glucose concentrations were controlled by an insulin-glucose clamp.<bold>Results: </bold>The median time for emptying 50% of the liquid phase from the stomach (T50) was 24.9 min (range 13.9-120.0) during normoglycemia compared with 8.1 min (range 3.6-16.5) during hypoglycemia without atropine infusion (P = 0.0005). The T50 for the solid phase was 26.8 min (range 9.7-74.0) and 43.1 min (range 29-57.8), respectively (P = 0.007). During hypoglycemia with atropine infusion, T50 was 40.7 min (range 10.0-120.0) for the liquid phase and 111.4 min (range 38.9-120.0) for the solid phase, not statistically different from normoglycemic examinations.<bold>Conclusions: </bold>Cholinergic muscarinic blockade with atropine inhibits the increase in gastric emptying during hypoglycemia. Vagal activity seems to be an important determinant of gastric emptying during hypoglycemia.
- Publication
Diabetes Care, 1995, Vol 18, Issue 11, p1463
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.18.11.1463