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- Title
Insulinoma in a patient with NIDDM.
- Authors
KANE, L. A.; GRANT, C. S.; NIPPOLDT, T. B.; SERVICE, F. J.
- Abstract
<bold>Objective: </bold>To confirm insulinoma as the cause of hypoglycemia in a patient with NIDDM and determine the frequency of the co-occurrence of these two conditions.<bold>Research Design and Methods: </bold>The patient underwent an in-hospital prolonged fast (< or = 72 h), according to standard protocol, and an ultrasound examination of the pancreas. All cases of histologically confirmed insulinoma at this institution over the period of 1927-1992 were reviewed to determine the prevalence of pre-existent diabetes mellitus.<bold>Results: </bold>After 10 h of fasting, plasma glucose was low (1.89 mM); plasma insulin (258 pM) and C-peptide (1.39 nM) were elevated in the absence of sulfonylurea in the plasma. An insulinoma detected by ultrasonography was removed surgically with subsequent reoccurrence of insulin-requiring diabetes. Among 313 cases of insulinoma confirmed at this institution, this patient is the only one with pre-existent diabetes mellitus.<bold>Conclusions: </bold>Insulinoma occurs extraordinarily rarely in patients with pre-existing NIDDM.
- Subjects
INSULIN therapy; TYPE 2 diabetes complications; BLOOD sugar; HYPOGLYCEMIA; ISLANDS of Langerhans tumors; LONGITUDINAL method; TYPE 2 diabetes; PANCREATIC tumors; DISEASE complications
- Publication
Diabetes Care, 1993, Vol 16, Issue 9, p1298
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.16.9.1298