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- Title
Clinicopathologic Characteristics and Mutational Status of Succinate Dehydrogenase Genes in Paraganglioma of the Urinary Bladder.
- Authors
Sanghui Park; So Young Kang; Ghee Young Kwon; Ji Eun Kwon; Sang Kyum Kim; Ji Yeon Kim; Chul Hwan Kim; Hyun-Jung Kim; Kyung Chul Moon; Ju Yeon Pyo; Won Young Park; Eun Su Park; Ji-Youn Sung; Sun Hee Sung; Young-Ha Oh; Seung Eun Lee; Wonae Lee; Jong Im Lee; Nam Hoon Cho; Soo Jin Jung
- Abstract
Context.--Because of the limited number of available primary bladder paraganglioma (PBPG) cases, the rates of succinate dehydrogenase (SDH) mutations and the clinicopathologic characteristics of SDH-deficient tumors have not been fully studied. Objective.--To define the clinicopathologic and molecular characteristics of PBPGs. Design.--A total of 52 PBPGs were collected retrospectively. SDHA and SDHB immunohistochemical stains were performed. In cases of SDHB expression loss, mutation analyses of SDHB, SDHC, and SDHD were performed. Results.--The clinicopathologic features were analyzed for 52 cases (M:F = 27:25), with a mean age of 56 years (range, 22-79 years). Tumor sizes were 0.5 to 8 cm (mean, 2.4 cm). Tumor necrosis was present in 5 of 52 cases (10%), involvement of muscularis propria in 41 (79%), and lymphovascular tumor invasion in 6 (12%). During a mean follow-up period of 41 months (range, 1-161 months), 3 of 52 patients (6%) developed metastases, but no one died from the disease. Immunohistochemistry for SDHA and SDHB showed that all cases were SDHA intact. Among them, 43 cases had intact SDHB, whereas 9 cases were SDHB deficient. Compared with the SDHB-intact cases, the SDHB-deficient cases were characterized by large tumor sizes (4.5 versus 1.9 cm; P < .001), a higher number of mitoses per 10 high-powered fields (2.6 versus 0.1; P = .002), and frequent lymphovascular tumor invasion (33% versus 7%; P = .02) and metastases (22% versus 2%; P=.02). Mutational analyses for SDHB, SDHC, and SDHD were performed in 9 SDHB-deficient cases. Among them, 6 cases were successfully sequenced and revealed SDHB mutations only. Conclusions.--Large tumor size, a higher number of mitoses, and the presence of lymphovascular tumor invasion and SDHB mutations suggest malignant paraganglioma.
- Subjects
KOREA; BLADDER tumors; IMMUNOHISTOCHEMISTRY; GENETIC mutation; OXIDOREDUCTASES; POLYMERASE chain reaction; PROBABILITY theory; RESEARCH funding; RETROSPECTIVE studies; PARAGANGLIOMA; SEQUENCE analysis; GENETICS
- Publication
Archives of Pathology & Laboratory Medicine, 2017, Vol 141, Issue 5, p671
- ISSN
0003-9985
- Publication type
Article
- DOI
10.5858/arpa.2016-0403-OA