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- Title
Cytotoxic Cembranes from Indonesian Specimens of the Soft Coral Nephthea sp.
- Authors
Januar, Hedi Indra; Chasanah, Ekowati; Motti, Cherie A.; Tapiolas, Dianne M.; Liptrot, Catherine H.; Wright, Anthony D.
- Abstract
Methanol extracts of two specimens of the soft coral Nephthea sp. collected from the Seribu Islands, Indonesia, were active in an anticancer bioassay. One new (1) and four known diterpenes (2-5) based on the cembrane carbon skeleton were isolated from these extracts, as was arachidonic acid (8). The structures of all compounds were elucidated using NMR, including 1,1-ADEQUATE and 1D gradient selective NOESY where applicable to determine the relative stereochemistry. Spectroscopic data, including 1H and 13C NMR, UV, IR and optical rotations are reported when enough material was available and where this has not been done previously. Inhibition assays employing three cancer cell lines; SF-268 (CNS), MCF-7 (breast), and H460 (lung) were used to guide the isolation of all compounds.
- Subjects
ANTINEOPLASTIC agents; METHANOL; ALCYONACEA; BIOLOGICAL assay; ARACHIDONIC acid; DITERPENES; NUCLEAR magnetic resonance; STEREOCHEMISTRY; MARINE pharmacology
- Publication
Marine Drugs, 2010, Vol 8, Issue 7, p2142
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md8072142