We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Erken Dönem Diyabetik Nöropati Hastalarda Dorsal Sural Sinir İletim Çalışmaları ve Adiponektin ve hs-CRP Düzeyleri ile İlişkileri.
- Authors
Kökoğlu, Fatma; Leventoğlu, Alev; Erdemoglu, A. Kemal
- Abstract
Objective: In this study, we aimed to investigate the change in dorsal sural nerve (DSN) conduction studies in early diabetic neuropathic patients and to evaluate whether high sensitive C-reactive protein (hs-CRP), inflammatory marker, and adiponektin, important role in insulin resistance and diabetes, have any effect on DSN studies or not. Material and Method: Forty-six patients with early stages (Dyck classification N1) diabetic neuropathy and age-sex matched forty-four control subject were included in the study. Informed consent was obtained after approval of ethical committee. In all subject DSN conduction studies were performed with conventional electrophysiological studies. DSN electrophysiological parameters of diabetics were compared with controls. The relationship between plasma adiponectin and hs-CRP levels and DSN conduction study parameters were analyzed. Results: In diabetic patients, DSN parameters were significantly different than controls. The level of adiponectin was found to be lower in diabetic (p:0.01) but not statistically significant for hs-CRP levels (p:0.40). There was not any relationship between DSN parameters and the level of adiponectin or hs-CRP (p>0.05). Sixty-three % of diabetics, whom routine electrophysiological studies were in normal limits, had abnormal DSN parameters. Fifty% of diabetics had bilateral abnormalities. However, there was no difference in hs-CRP and adiponectin levels between patients with abnormal and normal DSN studies (p>0.05). Conclusion: DSN studies are useful methods to detect subclinical early diabetic polyneuropathy according to the results of our study. Although adiponectin level was found lower in early diabetic neuropathic patients, both adiponectin and hs-CRP do not have any relationship with DSN studies.
- Subjects
DIABETIC neuropathies; DIABETES complications; NEUROPATHY; PROTEINS; MEDICAL care; PATIENTS
- Publication
Journal of Neurological Sciences, 2009, Vol 26, Issue 4, p404
- ISSN
1300-1817
- Publication type
Article