We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Combined Effect of Dietary Acid Load and Cardiometabolic Syndrome on Bone Resorption Marker among Post-Menopausal Women in Malaysia.
- Authors
LIM Sook Yee; CHAN Yoke Mun; CHIN Yit Siew; Mohd Shariff, ZALILAH; RAMACHANDRAN, Vasudevan; ARUMUGAM, Manohar
- Abstract
Background: This study aimed to investigate factors associated with bone resorption status and determine the independent and interactive effects of dietary acid load (DAL) and cardiometabolic syndrome (CMS) on bone resorption in post-menopausal women. Methods: Overall, 211 community-dwelling post-menopausal women were recruited from the National Council of Senior Citizens Organization, Malaysia. DAL was estimated using the potential renal acid load from the food frequency questionnaire. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and smoking behaviour was assessed using the Global Adult Tobacco Survey 2011. Serum 25(OH) vitamin D levels were determined using the ADVIA Centaur vitamin D assay and serum C-terminal telopeptides of type I collagen (CTX1) were used as surrogate markers to assess bone resorption. CMS was determined based on the harmonised criteria. Results: Age (β = --0.145, t = --2.002, P < 0.05) was negatively associated while DAL (β = 0.142, t = 2.096, P < 0.05) and sleep quality (β = 0.147, t = 2.162, P < 0.05) were positively associated with CTX1. Height was positively correlated with CTX1 (r = 0.136, P <0.05). Conversely, other variables (CMS traits, CMS, serum 25(OH) vitamin D level, years of menopause, years of education and physical activity) were not significantly associated with CTX1 levels. There was no significant interaction between DAL and CMS on bone resorption. Conclusion: Our findings propose that high DAL, but not CMS, is a potential risk factor for bone resorption. The analysis did not demonstrate the combined effects of DAL and CMS on bone resorption.
- Subjects
MALAYSIA; BONE resorption; CROSS-sectional method; PHYSICAL diagnosis; PEARSON correlation (Statistics); LIFESTYLES; CARDIOVASCULAR diseases; RESEARCH funding; SMOKING; CARDIOVASCULAR diseases risk factors; POSTMENOPAUSE; DESCRIPTIVE statistics; DISEASES; METABOLIC syndrome; STATISTICS; ACID-base equilibrium; SLEEP quality; DATA analysis software; BIOMARKERS; VITAMIN D
- Publication
Malaysian Journal of Medical Sciences, 2024, Vol 31, Issue 2, p113
- ISSN
1394-195X
- Publication type
Article
- DOI
10.21315/mjms2024.31.2.10