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- Title
A Pilot Study to Compare the Effect of Honey on Spermatogenesis In Rats Exposed to Cigarette Smoke.
- Authors
M., Mahaneem; S., Amrah; M. N., Islam; M. I., Zul Izhar; M. K., Yatiban; A., Nasir
- Abstract
BACKGROUND Cigarette smoke has been postulated to produce an oxidative stress in testes resulting in an abnormal spermatogenesis. Honey contains a variety of substances that act as antioxidant. Hence, this pilot study was undertaken to compare the effect of honey on spermatogenesis in rats following chronic exposure to cigarette smoke. MATERIALS AND METHODS Two male Sprague-Dawley rats, aged 10 weeks (310-360g) were placed in a chamber and exposed to cigarette smoke for 10 minutes, 3 times/day for 30 days. One of the rats was also treated with 1.2 g/kg/day of honey by gavaging. General health and body weight of the animals were monitored daily and weekly, respectively. At the end of the study, animals were sacrificed and organs including epididymis and testes were carefully removed and studied. RESULTS The rat treated with honey had higher sperm and spermatid counts, lower percentage of abnormal sperms and body weight loss as well as slightly larger diameter of testicular seminiferous tubules and interstitial spaces when compared to those of the other rat. CONCLUSION Honey appeared to reduce the toxic effect of cigarette smoke on spermatogenesis in this rat. Further study is needed to validate these findings.
- Subjects
HONEY; SPERMATOGENESIS in animals; RATS; CIGARETTE smoke; SPERMATOZOA; WEIGHT loss
- Publication
Malaysian Journal of Medical Sciences, 2007, Vol 14, Issue 1, p126
- ISSN
1394-195X
- Publication type
Article