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- Title
The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A.
- Authors
Weisser, Melanie; Voigts-Hoffmann, Felix; Rabl, Julius; Leibundgut, Marc; Ban, Nenad
- Abstract
Eukaryotic translation initiation factors (eIFs) 1A and 1 are central players in the complex process of start-codon recognition. To improve mechanistic understanding of this process, we determined the crystal structure of the 40S ribosomal subunit in complex with eIF1A and eIF1 from Tetrahymena thermophila at a resolution of 3.7 Å. It reveals the positions of the two factors on the 40S and the conformational changes that accompany their binding.
- Subjects
EUKARYOTIC cell genetics; TRANSLATION initiation factors (Biochemistry); GENETIC translation; CRYSTAL structure; RIBOSOMAL proteins; TETRAHYMENA thermophila; BACTERIA
- Publication
Nature Structural & Molecular Biology, 2013, Vol 20, Issue 8, p1015
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.2622