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- Title
Synthesis and Evaluation of Two Coumarin-Type.
- Authors
Mertens, Matthias D.; Gütschow, Michael
- Abstract
ABSTRACT The synthesis of two fluorescent coumarin-type chiral agents ( 4 and 11) is reported. A chiral side chain was introduced at position 7 of the coumarin via . The two coumarins bear in this side chain either a free amino group or a carboxyl group, making them useful for . Conjugates of chiral prototype drugs with 4 or 11 were prepared by amide coupling of the analyte's carboxyl group to the reagent's amine group, or vice versa. The separation of seven diastereomeric conjugates through achiral high-performance (HPLC) on a common C18 column is demonstrated. Chirality 25:957-964, 2013. © 2013 Wiley Periodicals, Inc.
- Subjects
COUMARINS; MITSUNOBU reaction; FLUORIMETRY; DIASTEREOISOMERISM; HIGH performance liquid chromatography; DIASTEREOISOMERS synthesis; PHARMACEUTICAL research
- Publication
Chirality, 2013, Vol 25, Issue 12, p957
- ISSN
0899-0042
- Publication type
Article
- DOI
10.1002/chir.22240