We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Recent advances in carbohydrate-based cancer vaccines.
- Authors
Jin, Ke-Tao; Lan, Huan-Rong; Chen, Xiao-Yi; Wang, Shi-Bing; Ying, Xiao-Jiang; Lin, Yan; Mou, Xiao-Zhou
- Abstract
Cancer is a complex multifactorial disease for which many promising therapeutic strategies such as immunotherapy are emerging. Malignant cells frequently express aberrant cell surface carbohydrates, which differentiate them from normal "healthy" cells. This characteristic presents a window for the development of synthetic carbohydrate antigen-based cancer vaccines which can be recognized by the immune system and can bring about T cell-dependent immune responses. Antibodies generated against the carbohydrate antigens partake in the inactivation of carbohydrate-decorated cancer cells, by slowing down tumor cell growth and inducing cancer cell apoptosis. Novel synthetic strategies for carbohydrate antigens have led to several synthetic cancer vaccine candidates. In the present review, we describe the latest progress in carbohydrate-based cancer vaccines and their clinical evaluation in various cancers.
- Subjects
IMMUNOTHERAPY; CARBOHYDRATES; CANCER treatment; CELL proliferation; TUMORS
- Publication
Biotechnology Letters, 2019, Vol 41, Issue 6/7, p641
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1007/s10529-019-02675-5