We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Biotransformation of 20( S)-protopanaxatriol by Mucor racemosus and the anti-cancer activities of some products.
- Authors
Chen, Guangtong; Ge, Hongjuan; Song, Yan; Li, Jianlin; Zhai, Xuguang; Wu, Juanjuan; Ling, Xiang
- Abstract
Objective: To produce new derivatives of 20( S)-protopanaxatriol by fungal biotransformation. Result: Biotransformation of 20( S)-protopanaxatriol ( 1) by Mucor racemosus AS 3.205 afforded six products. Their structures were elucidated on the basis of extensive spectroscopic analyses. M. racemosus could selectively catalyze dehydrogenation at C-12 and further hydroxylation at C-7, C-11, and C-15, as well as rearrangement of double bond at C-26. Two of these new compounds exhibited potent inhibitory activity against SH-SY5Y and HepG2 cell lines. Conclusion: Biotransformation by M. racemosus AS 3.205 was an effective approach to produce new derivatives of 20( S)-protopanaxatriol.
- Subjects
BIOTECHNOLOGY research; ANTINEOPLASTIC agents; BIOCATALYSIS; BIOTRANSFORMATION (Metabolism); DEHYDROGENATION; MUCOR; FUNGI
- Publication
Biotechnology Letters, 2015, Vol 37, Issue 10, p2005
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1007/s10529-015-1877-2