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- Title
Changes in serum interleukin-6 and high-sensitivity C-reactive protein levels in patients with acute coronary syndrome and their responses to simvastatin.
- Authors
Yumei Luo; Deqian Jiang; Dan Wen; Jianxin Yang; Liying Li
- Abstract
The role of inflammation in acute coronary syndrome (ACS) and the mechanism by which statin treats ACS is explored. Serum high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels were measured in 50 patients with ACS [including 30 cases with unstable angina (UA) and 20 patients with acute myocardial infarction (AMI)], 34 patients with stable angina (SA), and 30 controls. Patients in the ACS group were randomly assigned to a simvastatin group (including a simvastatin AMI subgroup,n= 11 and a simvastatin UA subgroup,n= 14) and a routine group (including a routine AMI subgroup,n= 9 and a routine UA subgroup,n= 16). The simvastatin group was given simvastatin 20?mg/day and the routine group a placebo. After a 3-week follow-up, serum hs-CRP, IL-6 levels, and serum lipid concentrations were measured again. Both serum IL-6 and hs-CRP levels were significantly higher in the ACS group (including the UA and AMI subgroups) than in the SA and control groups (P<0.001). After 3 weeks of treatment with simvastatin, the serum IL-6, hs-CRP, total cholesterol, and low-density lipoprotein cholesterol levels were decreased significantly in the simvastatin group (P<0.001), but no significant changes were observed in the routine group. No relationship was observed between the rate of decrease of serum IL-6 or hs-CRP and serum lipids levels. The hs-CRP level showed a significant correlation with IL-6 by Spearman’s rank correlation analysis (P<0.01). Inflammation plays an important role in the initiation of ACS. Simvastatin possesses an anti-inflammatory effect, independent of its lipid-lowering action, which may play an important role in the early treatment of ACS.
- Subjects
SERUM; INTERLEUKIN-6; C-reactive protein; STATINS (Cardiovascular agents); THERAPEUTICS; HEART diseases; PATIENTS; MYOCARDIAL infarction; ANGINA pectoris
- Publication
Heart & Vessels, 2004, Vol 19, Issue 6, p257
- ISSN
0910-8327
- Publication type
Article
- DOI
10.1007/s00380-004-0776-6