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- Title
Can R<sub>2</sub>' mapping evaluate hypoxia in renal ischemia reperfusion injury quantitatively? An experimental study.
- Authors
Zhang, Jinggang; Chen, Jie; Chen, Qin; Chen, Jing; Luo, Kai; Pan, Liang; Zhang, Yongcheng; Dou, Weiqiang; Xing, Wei
- Abstract
Purpose: To explore if R2' mapping can assess renal hypoxia in rabbits with ischemia reperfusion injury (IRI). Methods: Forty rabbits were randomly divided into 4 groups according to the clipping time: the sham group and 45 min, 60 min, and 75 min for the mild, moderate, and severe groups (with n = 10 each group), respectively. Intravenous furosemide (FU) was administered 24 h after IRI. All rabbits were performed 5 times (IRIpre, IRI24h, FU5min, FU12min, and FU24min) with a 3.0 Tesla MR. The R2' values and the hypoxic scores were then recorded. The repeated measurement analysis of variance and Spearman correlation analysis was used for statistical analysis. Results: Compared to the baseline, the medullary R2' values increased significantly 24 h after the IRI (baseline 19.31 ± 1.21 s‐1, mild group 20.05 ± 1.26 s−1, moderate group 25.38 ± 1.38 s−1, and severe group 25.79 ± 1.10 s−1; each P <.001). FU led to a significant decrease in the medullary R2' value (sham group 11.17 ± 4.33 s−1, mild group 7.80 ± 0.74 s−1, moderate group 3.92 ± 0.28 s−1, and severe group 3.82 ± 0.23 s−1; each P <.05). Quantitative hypoxic scores revealed significant differences among the 4 groups in the outer medulla (P <.001 each). The medullary R2' differences (before and after intravenous FU) were significantly correlated with the hypoxic scores, respectively (P <.001). Conclusion: R2' mapping can evaluate the renal hypoxia in the procession of IRI in rabbits and might serve as a quantitative biomarker for IRI.
- Subjects
REPERFUSION injury; HYPOXEMIA; ISCHEMIA; RANK correlation (Statistics)
- Publication
Magnetic Resonance in Medicine, 2021, Vol 86, Issue 2, p974
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.28696