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- Title
Prognostic Evaluation of Curatively Resected Locally Advanced Gastric Cancer Patients with Preoperative Downstaging Chemotherapy Assessed by Histochemical and Pharmacologic Means.
- Authors
Nakano, Hiroshi; Namatame, Kimio; Suzuki, Takao; Kim, Junkichi; Sasaki, Jun; Nagasaki, Hideaki; Makuuchi, Mikio; Kumada, Kaoru
- Abstract
The aim of the present study was to investigate whether the rate of thymidylate synthetase inhibition (TSIR) and the rate of proliferating cell nuclear antigen expression (PCNA-R) in gastric cancer tissues, which can be obtained within a short period after surgery, were predictive and quantitative prognostic factors for locally advanced gastric cancer patients with preoperative down-staging chemotherapy. Curatively resected 30 locally advanced gastric cancer patients with preoperative chemotherapies were studied. Three-year survival analysis showed that the higher TSIR and the lower PCNA-R significantly predicted better prognosis (p < 0.01 and p < 0.05, respectively). Multiple regression test showed that the TSIR was a significantly predictive variable for 1-year survival (p < 0.05). The TSIR and PCNA-R could be predictive and quantitative prognostic factors in advanced gastric cancer patients who received preoperative downstaging chemotherapy. Copyright © 1995 S. Karger AG, Basel
- Publication
Oncology, 1995, Vol 52, Issue 6, p474
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000227514