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- Title
A Unique Case of Intra-Epidermal Neutrophilic Dermatosis-Type IgA Pemphigus Presenting with Subcorneal Pustules.
- Authors
Iida, Koji; Sueki, Hirohiko; Ohyama, Bungo; Ishii, Norito; Hashimoto, Takashi
- Abstract
Background: While subcorneal pustular dermatosis-type IgA pemphigus shows subcorneal pustules, intra-epidermal neutrophilic dermatosis (IEN)-type IgA pemphigus is characterised by pustule formation throughout the entire epidermis. Objective: We analysed an unusual case of IEN-type IgA pemphigus showing subcorneal pustules. Methods: Indirect immunofluorescence, immunoblot analysis, auto-antibody-specific ELISAs, and double-labelling immuno-electron microscopy were performed. Results: IgA antibodies bound to the surface of keratinocytes distributed throughout the epidermis were detected by indirect immunofluorescence. IgA from the patient's serum failed to react with COS-7 cells expressing desmocollins (Dsc) 1, 2 or 3. IgG or IgA antibodies against desmogleins 1 and 3 were also found to be absent by ELISA. Double-labelling immuno-electron microscopy using an anti-Dsc monoclonal antibody showed localisation in the desmosomes, while IgA from the patient's serum was found in non-desmosomal regions. Conclusion: The patient in the present study most likely suffers from IEN-type IgA pemphigus. Copyright © 2011 S. Karger AG, Basel
- Publication
Dermatology (10188665), 2011, Vol 222, Issue 1, p15
- ISSN
1018-8665
- Publication type
Article
- DOI
10.1159/000322839