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- Title
An Evaluation of the Efficacy of Vasoactive Intestinal Polypeptide Antagonists in vivo in the Anaesthetized Dog.
- Authors
Hennessy, B. A.; Fitzpatrick, M.; O’Sullivan, J.; Snow, H. M.; Markos, F.
- Abstract
The effectiveness of competitive peptide vasoactive intestinal polypeptide (VIP) receptor antagonists was evaluated on heart rate in the anaesthetized dog. Two specific antagonists, VIP (6–28) and [D-p-Cl-Phe[sup 6] , Leu[sup 17] ]-VIP, and a nonspecific antagonist, pituitary adenylate cyclase activating peptide fragment (6–27) (PACAP), were studied. VIP (6–28) and [D-p-Cl-Phe[sup 6] , Leu[sup 17] ]-VIP (100 μg i.c.) increased the heart rate, whereas PACAP (100 μg i.c.) reduced the baseline heart rate. All three shifted the VIP dose-response curve to the right by two- to threefold for 30 min. In conclusion, PACAP, VIP (6–28), and [D-p-Cl-Phe[sup 6] , Leu[sup 17] ]-VIP have a direct effect on the heart rate, are equally effective, and the effects last approximately 30 min in vivo.Copyright © 2002 S. Karger AG, Basel
- Subjects
VASOACTIVE intestinal peptide; PEPTIDE antibiotics; CHOLINERGIC receptors; GASTROINTESTINAL hormones; CARDIOGRAPHY; ADENYLATE cyclase; DRUG efficacy; ANIMAL anesthesia; LABORATORY dogs
- Publication
Pharmacology, 2002, Vol 66, Issue 4, p206
- ISSN
0031-7012
- Publication type
Article