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- Title
Microinflammation in Hemodialysis Patients Is Associated with Increased CD14<sup>+</sup>CD16<sup>+</sup> Pro-Inflammatory Monocytes: Possible Modification by On-Line Hemodiafiltration.
- Authors
Hye Won Kim; Ha-Na Yang; Myung Gyu Kim; Hye Min Choi; Sang-Kyung Jo; Won Yong Cho; Hyoung Kyu Kim
- Abstract
Background: An increased percentage of pro-inflammatory CD14+CD16+ monocytes might contribute to inflammation in hemodialysis (HD) patients. The purpose of the study was to evaluate the possible contribution of pro-inflammatory monocytes to inflammation in HD patients and also to evaluate the effect of on-line hemodiafiltration (HDF). Methods: Flow cytometric detection of monocytes in patients undergoing HD, on-line HDF and healthy controls as well as plasma cytokines and cytokine mRNA measurement were performed. Results: Percent pro-inflammatory monocytes, plasma cytokines and cytokine mRNA significantly increased in HD patients. Intracellular cytokine staining showed pro-inflammatory monocytes were the predominant source of tumor necrosis factor-α. Percent pro-inflammatory monocytes positively correlated with plasma inflammatory cytokines. Percent pro-inflammatory monocytes, plasma cytokines and cytokine mRNA significantly decreased in on-line HDF patients. Conclusion: Increased pro-inflammatory monocytes are likely to contribute to inflammation in HD patients, and beneficial effect of on-line HDF might be partially mediated by modulating the inflammatory response. Copyright © 2011 S. Karger AG, Basel
- Subjects
INFLAMMATION; HEMODIALYSIS; MONOCYTES; TUMOR necrosis factors; CELLULAR immunity; CYTOKINES; MESSENGER RNA
- Publication
Blood Purification, 2011, Vol 31, Issue 4, p281
- ISSN
0253-5068
- Publication type
Article
- DOI
10.1159/000321889