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- Title
Single embryo transfer in preimplantation genetic diagnosis cycles for women <36 years does not reduce delivery rate.
- Authors
P. Donoso; W. Verpoest; E.G. Papanikolaou; I. Liebaers; H.M. Fatemi; K. Sermon; C. Staessen; J. Van der Elst; P. Devroey
- Abstract
BACKGROUND The Belgian legislation imposes single embryo transfer (SET) on women of METHODS A retrospective analysis of PGD cycles for monogenic disorders and translocations in women RESULTS 62 cycles were included in the DET group and 73 cycles in the SET group. The mean age, number of cumulus–oocyte complexes, number of fertilized oocytes, number of biopsied and cryopreserved embryos were comparable between both groups. There was no significant difference in the delivery rates between the DET and the SET groups (33.9% versus 27.4%, respectively). Multiple pregnancies were avoided when SET was performed. When monogenic disorders and chromosomal translocations were separately evaluated, no significant difference in the delivery rate after SET was observed. CONCLUSIONS The implementation of a SET policy in young women undergoing PGD for monogenic disorders and translocations enables a significant reduction of multiple pregnancies without significantly affecting the delivery rate.
- Subjects
EMBRYO transfer; HUMAN embryo transfer; WOMEN'S health; DELIVERY (Obstetrics)
- Publication
Human Reproduction, 2007, Vol 22, Issue 4, p1021
- ISSN
0268-1161
- Publication type
Article
- DOI
10.1093/humrep/del470