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- Title
A facile and efficient method for the selective deacylation of <i>N</i>-arylacetamides and 2-chloro-<i>N</i>-arylacetamides catalyzed by SOCl<sub>2</sub>.
- Authors
Wang, Gong-Bao; Wang, Lin-Fa; Li, Chao-Zhang; Sun, Jing; Zhou, Guang-Ming; Yang, Da-Cheng
- Abstract
Thionyl chloride efficiently and selectively promoted the deacylation of N-arylacetamides and 2-chloro- N-arylacetamides, under anhydrous conditions, without effecting the ester group, aminosulfonyl group, or benzyloxyamide group. This method, which has been successfully applied to a variety of substrates including different N-arylacetamides and 2-chloro- N-arylacetamides, has the attractive advantages of inexpensive reagents, satisfactory selectivity, excellent yields, short reaction time, and convenient workup. This new method can probably be used to selectively deacylate between aromatic amides and alkyl amides.
- Subjects
ACETAMIDE; CATALYSIS; CHLORIDES; FUNCTIONAL groups; SUBSTRATES (Materials science); CHEMICAL reagents; CHEMICAL reactions
- Publication
Research on Chemical Intermediates, 2012, Vol 38, Issue 1, p77
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-011-0327-6