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- Title
Autophagy is essential for effector CD8<sup>+</sup> T cell survival and memory formation.
- Authors
Xu, Xiaojin; Araki, Koichi; Li, Shuzhao; Han, Jin-Hwan; Ye, Lilin; Tan, Wendy G; Konieczny, Bogumila T; Bruinsma, Monique W; Martinez, Jennifer; Pearce, Erika L; Green, Douglas R; Jones, Dean P; Virgin, Herbert W; Ahmed, Rafi
- Abstract
The importance of autophagy in the generation of memory CD8+ T cells in vivo is not well defined. We report here that autophagy was dynamically regulated in virus-specific CD8+ T cells during acute infection of mice with lymphocytic choriomeningitis virus. In contrast to the current paradigm, autophagy decreased in activated proliferating effector CD8+ T cells and was then upregulated when the cells stopped dividing just before the contraction phase. Consistent with those findings, deletion of the gene encoding either of the autophagy-related molecules Atg5 or Atg7 had little to no effect on the proliferation and function of effector cells, but these autophagy-deficient effector cells had survival defects that resulted in compromised formation of memory T cells. Our studies define when autophagy is needed during effector and memory differentiation and warrant reexamination of the relationship between T cell activation and autophagy.
- Subjects
AUTOPHAGY; T cells; IMMUNOLOGIC memory; ANIMAL models for virus diseases; LABORATORY mice; LYMPHOCYTIC choriomeningitis virus; CELL proliferation
- Publication
Nature Immunology, 2014, Vol 15, Issue 12, p1152
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.3025