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- Title
HISTOLOGICAL AND SCANNING STUDY ON THE LIVER OF NEWBORN AND ADULT WHITE SWISS MICE.
- Authors
AL-Zubaidi K. A.; Hirallah, Ahmed Ali K.
- Abstract
The current study was carried out to investigate the histological and ultrastructural changes that occurred in the liver of Swiss mice (Mus musculus) of different postnatal ages. To obtain this target, specimens from liver were collected from twenty mice at four different ages 1,10,30,60 postnatal days, which were set as (1st) day old (G1), 10th day (G2), 30th day (G3) and 60th day (G4) respectively. Routine histological stain, Harris Hematoxyline and Eosin (H&E) and Periodic Acid Schiff (PAS) in addition to scanning electronic microscope, were conducted to achieve current targets. The histological examination of liver revealed many events occurred with progress of ages, hematopoietic elements were decreased in number, the capsule was decrease in thickness which in adult was thinner than that in young. Also, the hepatocytes and there nucleus increased in volume with acquired hexagonal-shape. The sinusoids were decreased in diameter from high expansion to very narrow in adult stage. Central vein showed increasead in diameter. The portal area well-formed at 1st day old with contain 1-4 of bile ducts and increased in number of portal area up to adult. The glycogen was absent through the 1st day old and appeared at 10th day old up to adult with PAS stain. Adipose droplets were seen for first time in hepatocellular cytoplasmic in 30th day old with PAS. In the subsequent ages both their size and number of hematopoietic compartments were decrease. Hepatic liver lobules were initiated in 10th day old and in 30th day old the prominent boundaries were seen, Whereas, it well-formed at 60th day old. The sub-capsular hematopoietic elements appeared from 30th day old up to 60th day old. Scanning electronic microscope examination of liver revealed that the shape of hepatocyte change from polyhedral in 1st day old to hexagonal shape at the 30th day old. The hematopoietic foci seen at (G1) scattered throughout the parenchyma and become very rare, as a small foci at the (G2). The triad surrounded by the periportal plates or "limiting plates" and the central vein was have not valves. The present study concluded a many of histological changes which referred to development in the structural and functional of liver throughout the life span.
- Subjects
LIVER development; POSTNATAL care; HEMATOPOIESIS; SCANNING electron microscopes; ENDOCRINE function tests; CARDIAC output
- Publication
Plant Archives (09725210), 2020, Vol 20, Issue 1, p2175
- ISSN
0972-5210
- Publication type
Article