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- Title
Modeling of the Interaction of Cytochrome c with the Lipid Bilayer.
- Authors
Korotkova, P. D.; Yurchenko, A. A.; Timofeev, V. I.; Podshivalov, D. D.; Gusel'nikova, A. R.; Shumm, A. B.; Vladimirov, Y. A.
- Abstract
Interactions of horse heart cytochrome c (Cyt c) with the lipid bilayer consisting of tetraoleoyl cardiolipin molecules were studied by molecular dynamics simulations. It was shown that the Cyt c molecule can penetrate this lipid bilayer. The steps of this process and conformational changes of the Cyt c molecule upon interaction with the bilayer are described. These data can provide better insight into the molecular mechanism of apoptosis.
- Subjects
CYTOCHROME c; MOLECULAR dynamics; LIPIDS; CARDIOLIPIN
- Publication
Crystallography Reports, 2022, Vol 67, Issue 4, p590
- ISSN
1063-7745
- Publication type
Article
- DOI
10.1134/S1063774522030117