We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antinociceptive and Anti-inflammatory Activities of the Ethanolic Extract, Fractions and 8-Methoxylapachenol from Sinningia allagophylla Tubers.
- Authors
Barbosa, Felipe L.; Mori, Lídia S.; Riva, Dilamara; Stefanello, Maria Élida A.; Zampronio, Aleksander R.
- Abstract
This study investigated the antinociceptive and anti-inflammatory activities of the ethanolic extract ( EESAl), fractions and the compound 8-methoxylapachenol (8 ML) obtained from the tubers of Sinningia allagophylla. Male Swiss mice were treated with EESAl (3-300 mg/kg) or vehicle by oral route (p.o.) 1 hr before the injection of formalin 2.5% or carrageenan (Cg) into the hind paw. EESAl (3-30 mg/kg) reduced the inflammatory phase of the nociceptive behaviour induced by formalin (around 65% for all doses). EESAl (3-300 mg/kg, p.o.) also reduced Cg-induced mechanical hyperalgesia and oedema in a dose-dependent fashion but did not change the hot-plate latency or the motor performance of the animals. Oral administration of petroleum ether fraction ( PE, 3 mg/kg), but not in the methanolic fraction (30 mg/kg), reduced both Cg-induced oedema and hyperalgesia. Compound 8 ML isolated from PE (1.8 mg/kg, p.o.) abolished Cg-induced hyperalgesia but also did not change hot-plate latency or motor performance of the animals. 8 ML administration into the paw (0.75-750 pg) dose-dependently reduced Cg-induced hyperalgesia. 8 ML (750 pg) also blocked the hyperalgesia induced by tumour necrosis factor ( TNF-α), interleukin-1β ( IL-1β) and prostaglandin E2 ( PGE2) but failed to change the hyperalgesia induced by cytokine-induced neutrophil chemoattractant-1 ( CINC-1) and dopamine (Dopa). These results suggest that EESAl has an important antinociceptive and anti-inflammatory activity, the former one related, at least in part, to the reduction in the hyperalgesia. Similarly, 8 ML reduced Cg-induced oedema and mechanical hyperalgesia and seems to act in peripheral sites and on the prostaglandin rather than on the sympathetic component of the Cg-inflammatory hyperalgesia.
- Subjects
ANALGESICS; ANTI-inflammatory agents; MICE; TUBERS; ETHANOL; FRACTIONS
- Publication
Basic & Clinical Pharmacology & Toxicology, 2013, Vol 113, Issue 1, p1
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/bcpt.12051