We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
(R)-Ketamine Rapidly Ameliorates the Decreased Spine Density in the Medial Prefrontal Cortex and Hippocampus of Susceptible Mice After Chronic Social Defeat Stress.
- Authors
Zhang, Jiancheng; Qu, Youge; Chang, Lijia; Pu, Yaoyu; Hashimoto, Kenji
- Abstract
Background A recent study demonstrated that spine formation rates by ketamine in the prefrontal cortex (PFC) were not altered at 3–6 h following a single injection, but were markedly altered at 12–24 h. Here, we investigated the acute (3 h post-treatment) effects of (R)-ketamine in the decreased spine density in the medial PFC (mPFC) and hippocampus in susceptible mice after chronic social defeat stress (CSDS). Methods (R)-ketamine (10 mg/kg) or saline was administered intraperitoneally to CSDS-susceptible mice. Dendritic spine density in the mPFC and hippocampus was measured 3 h after a single injection. Results (R)-ketamine significantly ameliorated the decreased spine density in the prelimbic area of mPFC, Cornu Ammonis3, and dentate gyrus of the hippocampus of CSDS-susceptible mice Conclusions This study suggests that (R)-ketamine rapidly ameliorates the decreased spine density in the mPFC and hippocampus of CSDS-susceptible mice, resulting in its rapid-acting antidepressant effects.
- Subjects
HIPPOCAMPUS (Brain); PREFRONTAL cortex; DENTATE gyrus; SPINE; DENDRITIC spines; DENSITY
- Publication
International Journal of Neuropsychopharmacology, 2019, Vol 22, Issue 10, p675
- ISSN
1461-1457
- Publication type
Article
- DOI
10.1093/ijnp/pyz048