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- Title
A Genetic Variant in Proline and Serine Rich Coiled-Coil 1 Gene Is Associated with the Risk of Cardiovascular Disease.
- Authors
Khorrami, Mohammad Sadegh; Sadabadi, Fatemeh; Pasdar, Alireza; Safarian-Bana, Hamide; Amerizadeh, Forouzan; Esmaeily, Habibollah; Moohebati, Mohsen; Heidari-Bakavoli, Alireza; Ferns, Gordon; Ghayour-Mobarhan, Majid; Avan, Amir
- Abstract
Background: Cardiovascular disease is one of the most common causes of morbidity and mortality worldwide. The Proline and Serine Rich Coiled-Coil 1 gene in 1p13.3 locus has been reported to be associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD). The objective of this study was to investigate the association between the rs599839 polymorphism of the Proline and Serine Rich Coiled-Coil 1 (PSRC1) gene with CVD outcomes in a population sample recruited as part of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort. Methods: Five hundred and nine individuals who had an average follow-up period of 10 years were enrolled as part of the MASHAD cohort. DNA was extracted and genotyped using the TaqMan-real-time-PCR based method. Results: The study found individuals with GA/GG genotypes were at a higher risk of CVDs (OR= 4.7; 95% CI, 2.5-8.7; p< 0.001) in comparison to those with AA genotype; however, the result was not significant for GG genotype data. Conclusions: The results suggest that the GA/GG genotypes of the PSRC1gene locus were at increased risk of CVD in a representative population-based cohort, demonstrating further functional analysis to discover the value of emerging marker as a risk stratification biomarker to recognize high risk cases.
- Subjects
GENETIC variation; LDL cholesterol; PROLINE; CARDIOVASCULAR diseases; CARDIOVASCULAR diseases risk factors
- Publication
Reports of Biochemistry & Molecular Biology, 2022, Vol 10, Issue 4, p653
- ISSN
2322-3480
- Publication type
Article
- DOI
10.52547/rbmb.10.4.653