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- Title
Koryoamniyonit ve Fetal Etkileri.
- Authors
ONGUN, Hakan; ÇELİK, Kıymet; OYGÜR, Nihal
- Abstract
Chorioamnionitis is characterized by infection and/or inflammation of the chorion, amniotic fluid, umbilicus and the fetal membranes occuring after the 20th week of gestation. A large proportion of cases are subclinical and not diagnosed until retrospective analysis of the placenta. The most widely accepted route is, ascending of microorganisms from the maternal lower genital tract into the choriodecidual space and crossing the chorioamnionic membrane, thereby reaching the amniotic fluid and fetus, after rupture of membranes. However microorganisms can also reach the amniotic fluid without rupture. The routes to the fetus may be the migration of organisms from the maternal bloodstream across the placenta, anterograde infection from peritoneum via the fallopian tubes, iatrogenic inoculation during invasive procedures. For fetal involvement, bacterias invade the fetal vessels (choriovasculitis) or cross the amnion (amnionitis) into the amniotic cavity, reach the fetus through the respiratory or gastrointestinal tract, or through the mucous membranes (tympanic or conjunctiva). Ureaplasma species (U. parvum, U. urealyticum) and genital mycoplasmas (Mycoplasma hominis) are the most common microorganisms isolated from the amniotic fluid however, it may also occur in the absence of demonstrable microorganisms. The fetal inflammatory response syndrome is a condition characterized by systemic activation of the fetal innate immune system and multiple organ dysfunction due to infection/inflammation. It can be diagnosed with the detection of at least one of the findings of high interleukin-6 concentrations (>11 pg/mL) in fetal plasma and the histological chorioamnionitis/funisitis. Fetal inflammatory response syndrome results in multiorgan disfunction with its negative effects on fetal brain, lung, kidneys and heart.
- Subjects
AMNIOTIC liquid; GENITALIA; INFLAMMATION; FETAL membranes; FETAL brain; CHORIOAMNIONITIS; AMNIOTIC fluid embolism
- Publication
Turkiye Klinikleri Journal of Pediatrics / Türkiye Klinikleri Pediatri Dergisi, 2020, Vol 29, Issue 3, p175
- ISSN
1300-0381
- Publication type
Article
- DOI
10.5336/pediatr.2020-76142