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- Title
Formulation and In-Vitro Evaluation of Floating Pulsatile Drug Delivery System of Ivabradine.
- Authors
Kumar, Y. Ganesh; Pulla, Ravi Pratap; Ganesh, A.; Naresh, G.; Saleem, Afreen
- Abstract
The aim of present investigation was to develop press coated tablets for Floating pulsatile drug delivery of Ivabradine used for is a medication used for the symptomatic management of stable heart-related chest pain and heart failure not fully managed by beta blockers. The drug delivery system was designed to deliver the drug such a time when it could be needful of patient conditions. The press coated tablets containing Ivabradine in the inner core were formulated by direct compression method with an outer coating of different amount of HPMCK200 M. The release profile of press coated tablet exhibited a lag time. The optimized batch F9 gave good drug release of 99.58 %.
- Subjects
DRUG delivery systems; IVABRADINE; CHEST pain; DRUG utilization; HEART failure
- Publication
Journal of Drug Delivery & Therapeutics, 2019, Vol 9, Issue 3, p188
- ISSN
2250-1177
- Publication type
Article
- DOI
10.22270/jddt.v9i3.2862