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- Title
Food supplement with the adaptogenic activity on the basic of Agaricus bisporus biopolymers.
- Authors
Cherno, Natalya; Shafran, Leonid; Osolina, Sophya; Tretyakova, Olena; Nikitina, Oleksandra
- Abstract
Introduction. It is necessary to use the food supplement with the adaptogenic activity for correcting and preventing human state suffered from stress effect. Materials and methods. The samples were prepared by sequential treatment of mushrooms (Agaricus bisporus) with water, 3.7% HCl and sodium hydroxide solutions, varying the alkaline agent concentration (3.0, 5.0 and 7.0%) and its contact time with the solid residue (60, 120, 180, 240 and 300 min). Adaptogenic activity was predicted by the whole complex of indexes: the antioxidant activity (AOA), bifidogenic effect (BGE), sorption of cholic acid (SCA). The food supplement in a dose of 200 mg/kg was administered to the diet of experimental animals. The plumbum acetate in a dose of 14.1 mg/kg was stressor. The morphometric indexes, behavioral responses, and the levels of total lipids, cholesterol, triglycerides, malondialdehyde (MDA), the activities of ALT, AST, glutathione peroxidase (GP), glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G-6-PDG) were determined. Results. Correlation between the properties of samples of mushroom biopolymer complex and their preparation conditions (concentration of the alkaline agent, the treatment time) was investigated. It was shown that none of mushroom raw materials processing permitted to isolate the preparation that would show AOA, BGE, and SCA at the highest level. The sample that had AOA being equal to 90.0%, SCA - 22.4 mg/g of the supplement, BGE corresponding to 1.5·1012 CFU/cm³ was chosen for research in vivo test. A nutritional intervention of the food supplement against stressor influence had a beneficial effect on laboratory animals. There were improvement of morphometric indexes and stabilization of animals' behavioral responses. Activities of GP, GR, G-6-PDG increased by 21.7, 26.0, and 20.0% respectively compared to the animals group getting plumbum acetate. MDA, total lipids, triglycerides and cholesterol levels reduce by 14.8, 14.2, 26.6 and 18.9% respectively. The indexes of ALT and AST activities are stabilized. These results suggest that food supplement obtained from Agaricus bisporus has the adaptogenic activity. Conclusion. It is advisable to include this food supplement to the diet for correcting adaptative reactions of a human body.
- Subjects
DIETARY supplements; CULTIVATED mushroom; BIOPOLYMERS; SODIUM hydroxide; ANTIOXIDANTS; MORPHOMETRICS
- Publication
Ukrainian Food Journal, 2014, Vol 3, Issue 4, p577
- ISSN
2304-974X
- Publication type
Article