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- Title
Infectious complications following allogeneic stem cell transplantation: reduced-intensity vs. myeloablative conditioning regimens.
- Authors
Kim, S.‐H.; Kee, S.Y.; Lee, D.‐G.; Choi, S.‐M.; Park, S.H.; Kwon, J.‐C.; Eom, K.‐S.; Kim, Y.‐J.; Kim, H.‐J.; Lee, S.; Min, C.‐K.; Kim, D.‐W.; Choi, J.‐H.; Yoo, J.‐H.; Lee, J.‐W.; Min, W.‐S.
- Abstract
Background In allogeneic stem cell transplantation (allo- SCT), reduced-intensity conditioning ( RIC) is known for producing less regimen-related toxicity. However, whether or not RIC reduces the risk for infection and infection-related mortality ( IRM) remains controversial. Methods We retrospectively analyzed infectious episodes and IRMs after allo- SCTs by time period and by the intensity of the conditioning regimen ( RIC [ n = 81] vs. myeloablative conditioning, MAC [ n = 150]). Results The cumulative incidence of any kind of infection was lower in the RIC group through the entire period (72% vs. 87%; P = 0.007). The onset of infections was deferred in the RIC group as compared with the MAC group ( P = 0.012). Bacteremia occurred less frequently in the RIC group through the entire period (5% vs. 14%; P = 0.044). However, the incidences of cytomegalovirus reactivation and disease, herpes zoster, virus-associated hemorrhagic cystitis, and invasive fungal infection were not different between the two groups. Furthermore, there was no difference in relapse-free survival and IRM between the two conditioning regimens. Conclusion Careful monitoring and appropriate preventive/therapeutic strategies for infectious complications, comparable to those for allo- SCT recipients with MAC, should also be applied to those with RIC, especially after engraftment.
- Subjects
TRANSPLANTATION of organs, tissues, etc.; STEM cells; BACTERIAL diseases; HERPESVIRUS diseases; BLADDER diseases
- Publication
Transplant Infectious Disease, 2013, Vol 15, Issue 1, p49
- ISSN
1398-2273
- Publication type
Article
- DOI
10.1111/tid.12003