We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Efficacy and safety of anti‐interleukin‐1 in children with colchicine‐resistant familial Mediterranean fever.
- Authors
Erkilet, Hatice Kubra; Gezgin Yildirim, Deniz; Esmeray, Pelin; Söylemezoğlu, Oğuz
- Abstract
Background: The aim of this study was to evaluate the efficacy and safety of anti‐interleukin‐1 (IL‐1) therapies in colchicine‐resistant pediatric patients with familial Mediterranean fever (FMF). Methods: In this study, we retrospectively evaluated 656 children with FMF and 27 patients who had been treated with anti‐IL‐1 therapies (anakinra/canakinumab). Clinical and laboratory features, MEFV gene mutations, treatment responses were investigated. Results: Twenty of the patients were treated with anakinra (the treatment of 6 patients who initially used anakinra was switched to canakinumab in the follow‐up period), and 13 patients were treated with canakinumab. Clinical symptom and severity scores decreased in all patients A decrease in acute phase reactants was also observed in patients. A total of 18 (66%) patients had a M694V homozygous mutation, while 24 (89%) patients had a M694V mutation, at least in one allele. Conclusions: FMF patients with colchicine resistance may progress to amyloidosis. IL‐1 antagonist treatment could be used safely with a favorable outcome in pediatric patients with FMF resistance to colchicine therapy and/or who have renal amyloidosis.
- Subjects
TURKEY; THERAPEUTIC use of monoclonal antibodies; THERAPEUTIC use of proteins; DRUG efficacy; DISEASE progression; GENETIC mutation; GENERIC drug substitution; AMYLOIDOSIS; ANTI-inflammatory agents; ACUTE phase proteins; INTERLEUKIN-1; DRUG resistance; RETROSPECTIVE studies; ALLELES; SEVERITY of illness index; ANTIRHEUMATIC agents; DESCRIPTIVE statistics; COLCHICINE; PATIENT safety; AUTOINFLAMMATORY diseases; CHEMICAL inhibitors; EVALUATION; CHILDREN
- Publication
Pediatrics International, 2023, Vol 65, Issue 1, p1
- ISSN
1328-8067
- Publication type
Article
- DOI
10.1111/ped.15588