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- Title
Rotavirus-associated hemophagocytic lymphohistiocytosis ( HLH) after hematopoietic stem cell transplantation for familial HLH.
- Authors
Park, Meerim; Yun, Yeong Ju; Woo, Sung Il; Lee, Jae Wook; Chung, Nack‐Gyun; Cho, Bin
- Abstract
Hemophagocytic lymphohistiocytosis ( HLH) is a life-threatening disorder of immune regulation. HLH consists of two forms: familial and acquired, the latter which occurs in association with infection, malignancy, rheumatic disease and acquired immune deficiency. Herein, we report a case of acquired HLH in a child who had received allogeneic hematopoietic stem cell transplantation for familial HLH with UNC13D mutation. Based on microbiology, only rotavirus was identified as a possible organism triggering HLH. The patient's fulminant clinical course included acute respiratory failure, a sepsis-like pattern, disseminated intravascular coagulopathy, and rhabdomyolysis, leading to multiorgan failure and death from septic shock.
- Subjects
SOUTH Korea; HEMATOPOIETIC stem cell transplantation; PHYSICAL diagnosis; HEMOPHAGOCYTIC lymphohistiocytosis; RETROVIRUS diseases; SEPTIC shock; DISEASE management; DISEASE progression; ROUTINE diagnostic tests
- Publication
Pediatrics International, 2015, Vol 57, Issue 2, pe77
- ISSN
1328-8067
- Publication type
Article
- DOI
10.1111/ped.12567