We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The pleiotrophin-ALK axis is required for tumorigenicity of glioblastoma stem cells.
- Authors
Koyama-Nasu, R; Haruta, R; Nasu-Nishimura, Y; Taniue, K; Katou, Y; Shirahige, K; Todo, T; Ino, Y; Mukasa, A; Saito, N; Matsui, M; Takahashi, R; Hoshino-Okubo, A; Sugano, H; Manabe, E; Funato, K; Akiyama, T
- Abstract
Increasing evidence suggests that brain tumors arise from the transformation of neural stem/precursor/progenitor cells. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma. Here we show that anaplastic lymphoma kinase (ALK) and its ligand pleiotrophin are required for the self-renewal and tumorigenicity of glioblastoma stem cells (GSCs). Furthermore, we demonstrate that pleiotrophin is transactivated directly by SOX2, a transcription factor essential for the maintenance of both neural stem cells and GSCs. We speculate that the pleiotrophin-ALK axis may be a promising target for the therapy of glioblastoma.
- Subjects
BRAIN tumors; PLEIOTROPHIN; GLIOBLASTOMA multiforme; STEM cells; NEOPLASTIC cell transformation; ANAPLASTIC lymphoma kinase; TRANSCRIPTION factors; NEURAL stem cells; AUTOPOIESIS
- Publication
Oncogene, 2014, Vol 33, Issue 17, p2236
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/onc.2013.168